Ochoa-Fernandez R, Abel NB, Wieland F-G, Schlegel J, Koch L-A, Miller JB, Engesser R, Giuriani G, Brandl SM, Timmer J, Weber W, Ott T, Simon R and Zurbriggen MD “Optogenetic control of gene expression in plants in the presence of ambient white light”. Nature Methods (2020) DOI: 10.1038/s41592-020-0868-y

Blanco-Touriñan N, Legris M, Minguet EG, Costigliolo-Rojas C, Nohales MA, Iniesto E, Garcia-Leon M, Pacin M, Heucken N, Blomeier T, Locascio A, Cerny M, Esteve-Bruna D, Diez-Diaz M, Brzobohaty B, Frerigmann H, Zurbriggen MD, Kay SA, Rubio V, Blazquez MA, Casal JJ and Alabadi D “COP1 destabilizes DELLA proteins in Arabidopsis”. Proceedings of the National Academy of Sciences (PNAS) USA (2020) 117(24):13792-13799 DOI: 10.1073/pnas.1907969117

Niemeyer M, Moreno Castillo E, Ihling CH, Iacobucci C, Wilde V, Hellmuth A, Hoehenwarter W, Samodelov SL, Zurbriggen MD, Kastritis PL, Sinz A and Calderon-Villalobos LIA “Flexibility of intrinsically disordered degrons in AUX/IAA proteins reinforces auxin co-receptor assemblies”. Nature Communications (2020) 11:2277 DOI: 10.1038/s41467-020-16147-2

Müntjes K, Philipp M, Hüsemann L, Heucken N, Weidtkamp-Peters S, Schipper K, Zurbriggen MD and Feldbrügge M “Establishing polycistronic expression in the model microorganism Ustilago maydis”. Frontiers in Microbiology (2020) 11(1384) DOI: 10.3389/fmicb.2020.01384

Romero-Montepaone S, Poodts S, Fischbach P, Sellaro R, Zurbriggen MD and Casal JJ “Shade avoidance responses become more aggressive in warm environments”. Plant Cell and Environment (2020) DOI: 10.1111/pce.13720

Graz R, Brumbarova T, Ivanov R, Trofimov K, Tünnermann L, Ochoa-Fernandez R, Blomeier T, Meiser J, Weidtkamp-Peters S, Zurbriggen MD and Bauer P “Phospho-mutant activity assays provide evidence for alternative phospho-regulation pathways of the transcription factor FIT”. New Phytologist (2019) 225(1):350-267 DOI: 10.1111/nph.16168

Fischbach P, Gonschorek P, Baaske J, Davies JA, Weber W and Zurbriggen MD “Optogenetic downregulation of protein levels to control programmed cell death in mammalian cells with a dual blue-light switch”. Methods in Molecular Biology. Photoswitching proteins: Methods and Protocols. Springer (2020) 2173, DOI: 10.1007/978-1-0716-0755-8_11


Golonka D, Fischbach P, Jena SG, Kleeberg JRW, Essen L-O, Toettcher JE, Zurbriggen MD*/Möglich A* “Deconstructing an repurposing light-regulated protein:protein interactions of plant phytochromes” Communications Biology (2019), 2:448. *Corresponding authors

Roell MS, Zurbriggen MD “The impact of synthetic biology for future agriculture and nutrition” Current Opinion in Biotechnology (2019) 61:102-109

Andres J, Blomeier T, Zurbriggen MD* “Synthetic switches and regulatory circuits in plants” Plant Physiology (2019) DOI: 10.1104/pp.18.01362

Yousefi OS, Günther M, Hörner M, Chalupsky J, Wess M, Brandl SM, Smith RW, Fleck C, Kunkel T, Zurbriggen MD, Höfer T, Weber W, Schamel WWA “Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor” eLIFE (2019) 8:e42475 DOI: 10.7554/eLife.42475

Hörner M, Raute K, Hummel B, Madl J, Creusen G, ThomasOS, Christen EH, Hotz N, Gübeli RJ, Engesser R, Rebmann B, Lauer J, Rolauffs B, Timmer J, Schamel WWA, Pruszak J, Römer W, Zurbriggen MD, Freidrich C, Walther A, Minguet S, Sawarkar R, Weber W “Phytochrome-based extracellular matrix with reversibly tunable mechanical properties” Advanced Materials (2019) DOI: 10.1002/adma.201806727

Mayta M, Arce RC, Zurbriggen MD, Valle EM, Hajirezaei MR, Zanor MI, Carrillo N “Expression of a chloroplast-targeted cyanobacterial flavodoxin in tomato plants increases harvest index by altering plant size and productivity” Frontiers in Plant Science (2019) 10:1432

Nogueira M, Enfissi EMA, Welsch R, Beyer P, Zurbriggen MD, Fraser PD “Construction of a fusion enzyme for astaxanthin formation and its characterization in microbial and plant hosts: A new tool for engineering ketocarotenoids” Metabolic Engineering (2019) DOI: 10.1016/j.ymben.2018.12.006

Felemban A, Braguy J, Zurbriggen MD, Al-Babili S, “Apocarotenoids involved in plant development and stress response” Frontiers in Plant Science (2019), 10:1168



Baaske J/Gonschorek P, Engesser R, Dominguez-Monedero A, Raute K, Fischbach P, Müller K, Cachat E, Schamel WWA, Minguet S, Davies JA, Timmer J, Weber W*/Zurbriggen MD* "Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells" Scientific Reports (2018) DOI: 10.1038/s41598-018-32929-7 *Corresponding authors

Chatelle C, Ochoa-Fernandez R, Engesser R, Schneider N, Beyer HM, Jones A, Timmer J, Zurbriggen MD*/Weber W* "A green light-responsive system for the control of transgene expression in mammalian and plant cells" ACS Synthetic Biology (2018) DOI: 10.1021/acssynbio.7b00450 *Corresponding authors

Abbas M, Hernandez-Garcia J, Pollmann S, Samodelov SL, Kolb M, Friml J, Hammes UZ, Zurbriggen MD, Blazquez MA, Alabadi D "Auxin methylation is required for differential growth in Arabidopsis" Proceedings of the National Academy of Sciences (PNAS) USA (2018) DOI: 10.1073/pnas.1806565115

Beyer HM, Thomas OS, Riegel N, Zurbriggen MD, Weber W, Hörner M "Generic and reversible opto-trapping of biomolecules" Acta Biomaterialia (2018) DOI: 10.1016/j.actbio.2018.08.032

Middleton AM, Dal Bosco C, Chalp P, Nesch R, Harz H, Ren F, Bergamnn S, Wend S, Weber W, Hayaschi K-i, ZurbriggenMD, Uhl R, Ronneberger O, Palme K, Fleck C, Dovzhenko A "Data-driven modelling of intracellular auxin fluxes indicates a dominant role of the ER in controlling nuclear auxin uptake" Cell reports (2018) DOI: 10.1016/j.celrep.2018.02.074

Cagnola JI, Cerdan PD, Pacin M, Andrade A, Rodriguez V, Zurbriggen MD, Legris M, Buchovsky S, Carrillo N, Chory J, Blazquez MA; Alabadi D, Casal JJ "Long-day photoperiod enhances jasmonic acid-related plant defense" Plant Physiology (2018) DOI: 10.1104/pp.18.00443

Beyer HM, Engesser R, Hörner M, Koschmieder J, Beyer P, Timmer J, Zurbriggen MD, Weber W "Synthetic biology makes materials count" Advanced Materials (2018), DOI: 10.1002/adma.201800472



Samodelov SL and Zurbriggen MD “Quantitatively understanding plant signalling: novel theoretical-experimental approaches” Trends in Plant Science (2017) 22(8)

Winkler M, Niemeyer M, Hellmuth A, Janitza P, Christ G, Samodelov SL, Wilde V, Majovsky P, Trujillo M, Zurbriggen MD, Hoehenwarter W, Quint M, Calderon Villalobos LIA “Variation in auxin sensing guides AUX/IAA transcriptional repressor ubiquitylation and destruction” Nature Communications (2017) 8:15706

Pierella Karlusich JJ*/Zurbriggen MD*, Shahinnia F, Sonnewald S, Sonnewald U, Hosseini SA, Hajirezaei M-R, Carrillo N “Chloroplast redox status modulates genome-wide plant responses during the non-host interaction of tobacco with the hemibiotrophic bacterium Xanthomonas campestris pv vesicatoria” Frontiers in Plant Sciences (2017) 8:1158 *Equal contribution.

Iglesias MJ, Sellaro R, Zurbriggen MD, Casal JJ “Multiple links between shade avoidance and auxin networks” Journal of Experimental Botany (2017) doi:10.1093/jxb/erx295



Samodelov SL, Beyer HM, Guo X, Augustin M, Jia K-P, Beyer P, Weber W, Al-Babili S, Zurbriggen MD “StrigoQuant: a genetically encoded biosensor for quantifying strigolactone activity and specificity” Science Advances (2016) 2:e1601266

Smith RW, Helwig B, Westphal AH, Pel E, Hörner M, Beyer HM, Samodelov SL, Weber W, Zurbriggen MD, Borst JW and Fleck C “Unearthing the transition rates between photoreceptor conformers”. BMC Systems Biology (2016), accepted

Braguy J and Zurbriggen MD "Synthetic strategies for plant signalling studies: molecular toolbox and orthogonal platforms" Plant Journal (2016) accepted Special Issue Plant Synthetic Biology.



Beyer HM, Juillot S, Herbst K, Samodelov SL, Müller K, Schamel WW, Römer W, Schäfer E, Nagy F, Strähle U, Weber W and Zurbriggen MD, "Red light-regulated reversible nuclear localization of proteins in mammalian cells and zebra fish". ACS Synthetic Biology (2015) 4(7) Cover Article Issue July 2015

Ochoa-Fernandez R, Samodelov SL, Brandl SM, Wehinger E, Müller K, Weber W and Zurbriggen MD, "Optogenetics in plants: Red/far-red light control of gene expression". Optogenetics - Methods and Protocols. Methods in Molecular Biology, Springer (2015)

Kolar K, Wischhusen HM, Müller K, Karlsson M, Weber W and Zurbriggen MD, "A synthetic mammalian network to compute population borders based on engineered reciprocal cll-cell communication". BMC Systems Biology (2015) 9:97

Müller K, Zurbriggen MD and Weber W, "An optogenetic upgrade for the TET-OFF System". Biotechnology and Bioengineering (2015) DOI: 10.1002/bit.25562

Juillot S, Beyer HM, Madl J, Weber W, Zurbriggen MD and Römer W, "Signalling to the nucleus under the control of light and small molecules". Molecular BioSystems (2015) 12:345-349.

Beyer HM, Gonschorek P, Samodelov SL, Meier M, Weber W and Zurbriggen MD, "AQUA Cloning: a versatile and simple enzyme-free cloning approach". PLOS One (2015) DOI:10.1371/journal.pone.013765



Müller K, Engesser R, Timmer J, Zurbriggen MD and Weber W, "Orthogonal optogenetic triple-gene control in mammalian cells" ACS Synthetic Biology (2014) 3(11), 796-8901

Müller K, Naumann S, Weber W and Zurbriggen MD, "Optogenetics for gene expression in mammalian cells" Biological Chemistry (2014) 396(2), 145-152

Ketterer S, Hövermann D, Gübeli RJ, Bartels-Burgahn F, Riewe D, Altmann T, Zurbriggen MD, Junker B, Weber W and Meier M, "Transcription factor sensor system for parallel quantification of metabolites on-chip" Analytical Chemistry (2014) 86(24), 12152-12158

Müller K, Zurbriggen MD and Weber W, "Control of gene expression using a red/far-red light-responsive bi-stable toggle switch" Nature Protocols (2014) 9(3), 622-632

Müller K, Siegel D, Rodríguez Jahnke F, Gerrer K, Wend S, Decker EL, Reski R, Weber W and Zurbriggen MD, "A red light-controlled synthetic gene expression switch for plant systems" Molecular BioSystems (2014) 10, 1679-1688

Cabello JV, Lodeyro AF and Zurbriggen MD, "Novel perspectives for the engineering of abiotic stress tolerance" Current Opinion in Biotechnology (2014) 26, 62-70

Wend S, Wagner HJ, Müller K, Zurbriggen MD, Weber W and Radziwill G, "Optogenetic control of kinase activity in mammalian cells" ACS Synthetic Biology (2014) 3(5):280-285



Müller K and Zurbriggen MD, "Licht-gesteuerte Kontrolle der Genexpression in Säugerzellen" BIOspektrum (2013) 06.13 DOI:10.1007/s12268-013-0364-3

Wend S, Dal Bosco C, Kämpf MM, Ren F, Palme K, Weber W, Dovzhenko A and Zurbriggen MD, "A quantitative ratiometric sensor for time-resolved analysis of auxin dynamics" Scientific Reports (2013) 3:2052

Müller K, Engesser R, Schulz S, Steinberg T, Tomakidi P, Weber C, Ulm R, Nagy F, Timmer J, Zurbriggen MD and Weber W, "Multi-chromatic control of mammalian gene expression and signaling" Nucleic Acids Research (2013) 41(12), e124

Müller K, Engesser R, Timmer J, Nagy F, Zurbriggen MD and Weber W, "Synthesis of phycocyanobilin in mammalian cells" Chemical Communications (2013) 49(79), 8970-8972.

Müller K, Engesser R, Metzger S, Schulz S, Kämpf M, Busacker M, Steinberg T, Tomakidi P, Ehrbar M, Nagy F, Timmer J, Zurbriggen MD and Weber W, "A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells" Nucleic Acids Research (2013) 41(7), e77



Checa SK, Zurbriggen MD and Soncini FC, "Bacterial signaling systems as platforms for rational design of new generations of biosensors" Current Opinion in Biotechnology (2012) 23(5), 766-772.

Kämpf MM, Engesser R, Busacker M, Hörner M, Karlsson M, Zurbriggen MD, Fussenegger M, Timmer J and Weber W, "Rewiring and dosing of systems modules as a design approach for synthetic mammalian signaling networks" Molecular BioSystems (2012) 8(6), 1824-1832.

Zurbriggen MD, Moor A and Weber W, "Plant and bacterial systems biology as a platform for plant synthetic bio(techno)logy" Journal of Biotechnology (2012) 160(1-2), 80-90.



Zurbriggen MD, Carrillo N and Hajirezaei M-R. "ROS signaling in the hypersensitive response: when, where and what for?" Plant Signaling and Behavior (2010) 5(4), 393-396.

Zurbriggen MD, Hajirezaei M-R and Carrillo N. "Engineering the future. Development of transgenic plants with enhanced tolerance to adverse environments" Biotechnology and Genetic Engineering Reviews (2010) 27, 33-56.



Zurbriggen MD, Carrillo N, Tognetti VB, Melzer M, Peisker M, Hause B and Hajirezaei M-R. "Chloroplast-generated reactive oxygen species play a major role in localised cell death during the non-host interaction between tobacco and Xanthomonas campestris pv. vesicatoria" Plant Journal (2009) 60, 962-973.



Zurbriggen MD, Tognetti VB, Fillat MF, Hajirezaei M-R, Valle EM and Carrillo N. From the cover: "Combating stress with flavodoxin: a promising route for crop improvement" Trends in Biotechnology (2008) 26(10), 531-537. Cover Story of issue (10)26.

Böttcher C, Centeno D, Freitag J, Höfgen R, Köhl K, Kopka J, Kroymann J, Matros A, Mock HP, Neumann S, Pfalz M, von Roepenack-Lahaye E, Schauer N, Trenkamp S, Zurbriggen MD, Fernie AR. "Teaching (and learning from) metabolomics: The 2006 PlantMetaNet ETNA Metabolomics Research School" Physiologia Plantarum (2008) 132, 136-149.



Tognetti V*/Zurbriggen MD*, Morandi E, Fillat M, Valle E, Hajirezaei M-R and Carrillo N. From the cover: "Enhanced plant tolerance to iron starvation by functional substitution of chloroplast ferredoxin with a bacterial flavodoxin" Proceedings of the National Academy of Sciences (PNAS) USA (2007) 104, 11495-11500. From the cover article of issue 104. *Equal contribution.

Zurbriggen MD, Tognetti V and Carrillo N. "Stress-inducible Flavodoxin from photosynthetic microorganisms. The mistery of Flavodoxin loss from the plant genome'' Review. IUBMB Life (2007) 59(4), 1-6.



Rodriguez R, Lodeyro A, Poli H, Zurbriggen MD, Peisker M, Palatnik J, Tognetti V, Tschiersch H, Hajirezaei M, Valle E and Carrillo N. "Transgenic tobacco plants overexpressing chloroplastic Ferredoxin-NADP(H) reductase display normal rates of photosynthesis and increased tolerance to oxidative stress" Plant Physiology (2007) 143, 639-649. Editorial remarked article of issue 143. Book chapters peer reviewed, miscelaneous

Bühler B, Hollmann F, Junker B, Junne S, Küpfer L, Mao L, Marienhagen J, Muffler K, Noack S, Olbrich C, Rihko-Struckmann L, Schallmey A, Schmid J, Stafforst T, Steingroewer J and Zurbriggen MD. DECHEMA Diskussionspapier "Biotechnologie - der Schlüssel zur Bioökonomie". (2014)DECHEMA Zukunfstforum Biotechnologie. DECHEMA Gesellschaft für Chemische Technik und Biotechnologie, Frankfurt.

Rebmann B, van Hoogevest P, Zurbriggen MD and Weber W. "Spatiotemporally controlled delivery of biopharmaceuticals" In Animal Cell Biotechnology (Hansjörg Hauser and Roland Wagner, eds) (2015), pp 649-691. De Gruyter, Berlin/München/Boston. ISBN: 978-3-11-027886-6.

Zurbriggen MD*, Carrillo N and Hajirezaei MR. "Use of cyanobacterial proteins to engineer new crops"In Recent Advances in Plant Biotechnology (Kirakosyan, A. and Kaufman, P., eds) (2009), pp 65-88. Springer, New York, NY. ISBN: 978-1-4419-0193-4. 409 p. *Corresponding author.

Tognetti V*/Zurbriggen MD*, Valle EM, Carrillo N. Morandi E, Melzer M, Hajirezaei M-R and Fillat M. "Recovering the cyanobacterial heritage in land plants: the case of flavodoxin". In Flavins and Flavoproteins (Frago S, Gómez-Moreno C and Medina M eds.), (2008) Vol. 16, pp. 527-536, Prensas Universitarias de Zaragoza. ISBN: 978-8-4773-3017-4. 628 p. *Equal contribution.

Zurbriggen MD, Tognetti V, Valle EM and Carrillo N. "Cyanobacterial Flavodoxin provides multiple stress tolerance" ISB News Report (Irwin, R., ed.), (2007). Vol. 9-07, pp. 1-5. Information Systems for Biotechnology, Virginia Tech, Vicksburg, VA, US Department of Agriculture (USDA).



Weber W, Zurbriggen MD, Rebmann B (12/2013). Reversible PEGylation of nanocarriers.European Patent Application EP13195337.4

Weber W, Müller K, Zurbriggen MD, Kämpf M, Nagy F (2012). A light regulated transgene expression system.European Patent Application 12004422.7-2403 / International Patent Application PCT/EP2013/001650

Carrillo N, Giró M, Lodeyro A and Zurbriggen MD (2012). Stress Tolerant Plants.European Patent EP2464733

Carrillo N, Giró M, Lodeyro A and Zurbriggen MD (2011). Stress Tolerant Plants.International Patent WO2011/018662A1

Carrillo N, Giró M, Lodeyro A and Zurbriggen MD (2010). Stress Tolerant Plants.United States Patent US13/389665

Verantwortlich für den Inhalt: E-Mail sendenProf. Dr. Matias Zurbriggen