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Andres J, Schmunk LJ, Grau-Enguix F, Braguy J, Samodelov SL, Blomeier T, Ochoa-Fernandez R, Weber W, Al-Babili S, Alabadi D, Blazquez MA*/Zurbriggen MD* “Ratiometric gibberellin biosensors fort he analysis of signaling dxnamics and metabolism in plant protoplasts“ Plant Journal (2024) DOI: 10.1111/tpj.16725

*Corresponding authors

Wagner, Urquiza-Garcia U, Zurbriggen MD*/Beyer HM* “GMOCU: Digital documentation, management, and biological risk assessment of genetic parts“ Advanced Biology (2024) DOI: 10.1002/adbi.202300529

*Corresponding authors

Deen-Rozalen O, Nieke M, Shumka S, Beyer HM*/Zurbriggen MD* “The optogenetic landscape of the mitochondrion“

In The dynamic nature of mitochondria – From ultrastructure to health and disease (Andreas S Reichert ed) (2024) pp.151-184. CRC Francis & Taylor Press Boston. DOI: 10.1201/9781003221180


Jang J/Tang K, Youn J, McDonald S, Beyer HM, Zurbriggen MD*/Uppalapati M*/Woolley GA* “Engineering of Bidirectional, cyanobacteriochrome-based Light inducible dimers (BICYCL)s “. Nature Methods (2023) DOI: 10.1038/s41592-023-01764-8

*Corresponding authors

Molinari PE, Krapp AR, Weiner A, Beyer HM, Kondadi AK, Blomeier T, Lopez M, Bustos-Sanmamed P, Tever E, Weber W, Reichert AS, Calcaterra NB, Beller M, Carrillo N*/Zurbriggen MD* “NERNST: a genetically-encoded ratiometric non-destructive sensing tool to estimate NADP(H) redox status in bacterial, plant and animal systems”. Nature Communications (2023). Nat Commun. 2023 Jun 6;14(1):3277. DOI: 10.1038/s41467-023-38739-4.

*Corresponding authors

Heucken N/Tang K/Hüsemann L, Heßler N, Müntjes K, Feldbrügge M, Göhre V*/Zurbriggen MD* “Engineering and implementation of synthetic molecular tools in the Basidiomycete fungus Ustilago maydis”. Journal of Fungi (2023) DOI: 10.3390/jof9040480

Molinari PE, Krapp AR, Zurbriggen MD*/Carrillo N* “Lighting the light reactions of photosynthesis by means of redox-responsive genetically encoded biosensors for photosynthetic intermediates”. Photochemical and Photobiological Sciences (2023) DOI: 10.1007/s43630-023-00425-1

*Corresponding authors

Bournonville C, Mori K, Deslous P, Decros G, Blomeier T, Mauxion J-P, Jorly J, Gadin S, Cassan C, Maucourt M, Just D, Bres C, Rotahn C, Ferrand C, Fernandez-Lochu L, Bataille L, Miura K, Beven L, Zurbriggen MD, Petriacq P, Gibon Y, Baldet P “Blue light promotes ascorbate synthesis by deactivating the PAS/LOV photoreceptor that inhibits GDP-L-galactose phosphorylase”. Plant Cell (2023) DOI: 10.1093/plcell/koad108

Dunken N, Widmer H, Balcke GU, Straube H, Langen G, Charura NM, Saake P, De Quattro C, Schön J, Rövenich H, Wawra S, Djamei A, Zurbriggen MD, Tissier A, Witte C-P, Zuccaro A “A nucleoside signal generated by a fungal endophyte regulates host cell death and promotes root colonization”. bioRxiv (2023) DOI: 10.1101/2022.03.11.483938



Mor E/Pernisova M, Minne M, Cerutti G, Ripper D, Nolf J, Andres J, Ragni L, Zurbriggen MD*/De Rybel B*/Vernoux T* „bHLH heterodimer complex variations shape meristems in Arabidopsis thaliana by affecting target gene specificity”. iScience (2022) DOI: 10.1101/2022.06.02.494582.

*Corresponding authors

Ito S, Braguy J, Wang JY, Yoda A, Fiorilli V, Takahashi I, Jamil M, Felemban A, Miyazaki S, Mazzarella T, Chen G-T E, Shinozawa A, Balakrishna A, Berqdar L, Rajan C, Ali S, Haider I, Sasaki Y, Yajima S, Akiyama K, Lanfranco L, Zurbriggen MD, Nomura T, Asami T, Al-Babili S “Canonical strigolactones are not the major determinant of tillering but important rhizospheric signals in rice”. Science Advances (2022) 8, eadd1278 DOI: 10.1126/sciadv.add1278.

Matuszynska A*, Ebenhöh O*, Zurbriggen MD*, Ducat DC*, Axmann I* “Designing synthetic communities with organism-free modular computational models“. ChemRxiv (2022) DOI: 10.25434/chemrxiv-2022-r78kg.

*Corresponding authors

Costigliolo Rojas C, Bianchimano L, Oh J, Romero Montepaone S, Tarkowska D, Minguet EG, Schön J, Garcia Hourquet M, Flugel T, Blazquez MA, Choi G, Strnad M, Mora Garcia S, Alabadi D, Zurbriggen MD, Casal JJ “Organ-specific COP1 control of BES1 stability adjusts plant growth patterns under shade or warmth”. Developmental Cell (2022) DOI: 10.1016/j.devcel.2022.07.003.

Andres J and Zurbriggen MD „Genetically encoded biosensors for the quantitative analysis of auxin dynamics in plant cells”. Methods in Molecular Biology. Plant Synthetic Biology: Methods and Protocols. Springer (2022), 2379 DOI: 10.1007/978-1-0716-1791-5_11.

Thomas OS, Rebmann B, Tonn M, Schirmeister IC, Wehrle S, Becker J, Zea Gimenez GJ, Hook S, Jäger S, Klenzendorf M, Lasowski M, Kaier A, Pütz G, Zurbriggen MD, Weber W, Hörner M, Wagner HJ „Reversible shielding and immobilization of liposomes and viral vectors by tailored antibody-ligand interactions“. Small (2022) 18(6), 2105157 DOI: 10.1002/smll.202105157.

EFSA Panel on Genetically Modified Organisms (GMO), Mullins E, Bresson J-L, Dalmay T, Crawford Dewhurst I, Epstein MM, Fribank LG, Guerche P, Hejatko J, Moreno FJ, Nogue F, Rostoks N, Sanchez Seraano JJ, Savoini G, Veromann E, Veronesi F, Casacuberta J, Zurbriggen MD, Fernandez A, Gomez Ruiz JA, Gennaro A, Papadopoulou N, Lanzoni A, Naegeli H “Evaluation of existing guidelines for their adequacy for the food and feed risk assessment of genetically modified plants obtained through synthetic biology”. EFSA Journal (2022) 20(7)e07410 DOI: 10.2903/j.efsa.2022.7410.

Bournonville C, Mori K, Deslous P, Decros G, Blomeier T, Mauxion J-P, Jorly J, Gadin S, Cassan C, Maocourt M, Just D, Bres C, Rothan C, Ferrand C, Fernandez-Lochu L, Bataille L, Miura K, Beven L, Zurbriggen MD, Petriacq P, Gibon Y, Baldet P “Blue light promotes ascorbate synthesis by deactivating the PAS/LOV photoreceptor that inhibits GDP-L-galactose phosphorylase”. bioRxiv (2022) DOI: 10.1101/2022.12.12.520143.


Tang K/Beyer HM, Zurbriggen MD*/Gärtner W* “The red edge: Bilin-binding photoreceptors as optogenetic tools and fluorescence reporters”. Chemical Reviews (2021) 121(24), 14906-14956 DOI: 10.1021/acs.chemrev.1c00194.

*Corresponding authors

Schwarzländer M and Zurbriggen MD “Sensors & Controllers – For & From Plants“. Plant Physiology (2021) DOI: 10.1093/plphys/kiab364.

Hörner M, Jerez-Longres C, Hudek A, Hook S, Yousefi OS, Schamel WWA, Hörner C, Zurbriggen MD, Ye H, Wagner HJ, Weber W “Spatiotemporally confined red light-controlled gene delivery at single-cell resolution using adeno-associated viral vectors”. Science Advances (2021) 7:eabf0797 DOI: 10.1126/sciadv.abf0797.

Braguy J, Samodelov SL, Andres J, Ochoa-Fernandez R, Al-Babili S, Zurbriggen MD “A protoplast-based bioassay to quantify strigolactone activity in Arabidopsis using StrigoQuant”. Methods in Molecular Biology. Strigolactones: Methods and Protocols. Springer (2021), 2309 DOI: 10.1007/978-1-0716-1429-7_16.

Urquiza-Garcia U, Zurbriggen MD “Biofortifying green optogenetics”. Nature Plants (2021) 7(2):104-105 DOI: 10.1038/s41477-021-00860-x.

Blomeier T, Fischbach P, Koch L-A, Andres J, Miñambres M, Beyer HM, Zurbriggen MD “Blue light-operated CRISPR/Cas13b-mediated mRNA knockdown (Lockdown)”. Advanced Biology (2021) 2000307 DOI: 10.1002/adbi.202000307.

Christie JM* and Zurbriggen MD* “Optogenetics in plants”. New Phytologist (2021) 229:3108-3115 DOI: 10.1111/nph.17008.

Braguy J, Ramazanova M, Giancola S, Jamil M, Kountche BA, Zarban R, Felemban A, Wang JY, Lin P-Y, Haider I, Zurbriggen MD, Ghanem B, Al-Babili S “SeedQuant: a deep learning-based tool for assessing stimulant and inhibitor activity on root parasitic seeds”. Plant Physiology (2021) 186:1632-1644 DOI: 10.1093/plphys/kiab173.

Bolsius YG, Zurbriggen MD, Kim JK, Kas MJ, Meerlo P, Aton SJ, Havekes R “The role of the clock genes in sleep, stress and memory”. Biochemical Pharmacology (2021) 114493 DOI: 10.1016/j.bcp.2021.114493.

Schneider N, Chatelle CV, Ochoa-Fernandez R, Zurbriggen MD, Weber W “Green-light controlled gene switch for mammalian and plant cells“. Methods in Molecular Biology. Mammalian Cell Engineering: Methods and Protocols. Springer (2021), 2312 DOI: 10.1007/978-1-0716-1441-9_6.

EFSA Panel on Genetically Modified Organisms (GMO), Naegeli H, Bresson J-L, Dalmay T, Dewhurst IC, Epstein MM, Firbank LG, Guerche P, Hejatko J, Moreno FJ, Nogue F, Rostoks N, Sanchez Serrano JJ, Savoini G, Veromann E, Veronesi F, Casacuberta J, De Schrijver A, Messean A, Patron N, Zurbriggen MD, Alvarez F, Devos Y, Gennaro A, Streissl F, Papadopoulou N, Mullins E “Evaluation of the existing guidelines for their adequacy for the molecular characterisation and environmental risk assessment of genetically modified plants obtained through synthetic biology”. EFSA Journal (2021) e06301 DOI: 10.2903/j.efsa.2021.6301.


Ochoa-Fernandez R, Abel NB, Wieland F-G, Schlegel J, Koch L-A, Miller JB, Engesser R, Giuriani G, Brandl SM, Timmer J, Weber W, Ott T, Simon R and Zurbriggen MD “Optogenetic control of gene expression in plants in the presence of ambient white light”. Nature Methods (2020) 17:717-725 DOI: 10.1038/s41592-020-0868-y. Download.

Kahle N, Sheerin DJ, Fischbach P, Koch L-A, Schwenk P, Lambert D, Rodriguez R, Kerner K, Höcker U, Zurbriggen MD, Hiltbrunner A “COLD REGULATED 27 and 28 are targets of CONSTITUTIVELY PHOTOMORPHOGENIC 1 and negatively affect phytochrome B signaling”. Plant Journal (2020) 104:1038-1053 DOI: 10111/tpj.14979.

Pierella-Karlusich JJ, arce RC, Shahinnia F, Sonnewald S, Sonnewald U, Zurbriggen MD*/Hajirezaei M-R*/Carrillo N* “Transcriptional and metabolic profiling of potato plants expressing a plastid-targeted electron shuttle reveal modulation of genes associated to drought tolerance by chloroplast redox poise”. International Journal of Molecular Sciences (2020) 21(19):7199 DOI: 10.3390/ijms21197199*Corresponding authors

Blanco-Touriñan N, Legris M, Minguet EG, Costigliolo-Rojas C, Nohales MA, Iniesto E, Garcia-Leon M, Pacin M, Heucken N, Blomeier T, Locascio A, Cerny M, Esteve-Bruna D, Diez-Diaz M, Brzobohaty B, Frerigmann H, Zurbriggen MD, Kay SA, Rubio V, Blazquez MA, Casal JJ and Alabadi D “COP1 destabilizes DELLA proteins in Arabidopsis”. Proceedings of the National Academy of Sciences (PNAS) USA (2020) 117(24):13792-13799 DOI: 10.1073/pnas.1907969117.

Niemeyer M, Moreno Castillo E, Ihling CH, Iacobucci C, Wilde V, Hellmuth A, Hoehenwarter W, Samodelov SL, Zurbriggen MD, Kastritis PL, Sinz A and Calderon-Villalobos LIA “Flexibility of intrinsically disordered degrons in AUX/IAA proteins reinforces auxin co-receptor assemblies”. Nature Communications (2020) 11:2277 DOI: 10.1038/s41467-020-16147-2.

Müntjes K, Philipp M, Hüsemann L, Heucken N, Weidtkamp-Peters S, Schipper K, Zurbriggen MD and Feldbrügge M “Establishing polycistronic expression in the model microorganism Ustilago maydis”. Frontiers in Microbiology (2020) 11(1384) DOI: 10.3389/fmicb.2020.01384.

Romero-Montepaone S, Poodts S, Fischbach P, Sellaro R, Zurbriggen MD and Casal JJ “Shade avoidance responses become more aggressive in warm environments”. Plant Cell and Environment (2020) DOI: 10.1111/pce.13720

Graz R, Brumbarova T, Ivanov R, Trofimov K, Tünnermann L, Ochoa-Fernandez R, Blomeier T, Meiser J, Weidtkamp-Peters S, Zurbriggen MD and Bauer P “Phospho-mutant activity assays provide evidence for alternative phospho-regulation pathways of the transcription factor FIT”. New Phytologist (2019) 225(1):350-267 DOI: 10.1111/nph.16168.

Fischbach P, Gonschorek P, Baaske J, Davies JA, Weber W and Zurbriggen MD “Optogenetic downregulation of protein levels to control programmed cell death in mammalian cells with a dual blue-light switch”. Methods in Molecular Biology. Photoswitching proteins: Methods and Protocols. Springer (2020) 2173, DOI: 10.1007/978-1-0716-0755-8_11.

Roell MS and Zurbriggen MD “The impact of synthetic biology for future agriculture and nutrition”. Current Opinion in Biotechnology (2020) 61:102-109 DOI: j.copbio.2019.10.004.


Golonka D, Fischbach P, Jena SG, Kleeberg JRW, Essen L-O, Toettcher JE, Zurbriggen MD*/Möglich A* “Deconstructing an repurposing light-regulated protein:protein interactions of plant phytochromes” Communications Biology (2019), 2:448 DOI: 10.1038/s42003-019-0687-9*Corresponding authors

Roell MS, Zurbriggen MD “The impact of synthetic biology for future agriculture and nutrition” Current Opinion in Biotechnology (2019) 61:102-109 DOI: 10.1016/j.copbio.2019.10.004.

Andres J, Blomeier T, Zurbriggen MD* “Synthetic switches and regulatory circuits in plants” Plant Physiology (2019) DOI: 10.1104/pp.18.01362.

Yousefi OS, Günther M, Hörner M, Chalupsky J, Wess M, Brandl SM, Smith RW, Fleck C, Kunkel T, Zurbriggen MD, Höfer T, Weber W, Schamel WWA “Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor” eLIFE (2019) 8:e42475 DOI: 10.7554/eLife.42475.

Hörner M, Raute K, Hummel B, Madl J, Creusen G, ThomasOS, Christen EH, Hotz N, Gübeli RJ, Engesser R, Rebmann B, Lauer J, Rolauffs B, Timmer J, Schamel WWA, Pruszak J, Römer W, Zurbriggen MD, Freidrich C, Walther A, Minguet S, Sawarkar R, Weber W “Phytochrome-based extracellular matrix with reversibly tunable mechanical properties” Advanced Materials (2019) DOI: 10.1002/adma.201806727.

Mayta M, Arce RC, Zurbriggen MD, Valle EM, Hajirezaei MR, Zanor MI, Carrillo N “Expression of a chloroplast-targeted cyanobacterial flavodoxin in tomato plants increases harvest index by altering plant size and productivity” Frontiers in Plant Science (2019) 10:1432 DOI: 10.3389/fpls.2019.01432.

Nogueira M, Enfissi EMA, Welsch R, Beyer P, Zurbriggen MD, Fraser PD “Construction of a fusion enzyme for astaxanthin formation and its characterization in microbial and plant hosts: A new tool for engineering ketocarotenoids” Metabolic Engineering (2019) DOI: 10.1016/j.ymben.2018.12.006.

Felemban A, Braguy J, Zurbriggen MD, Al-Babili S, “Apocarotenoids involved in plant development and stress response” Frontiers in Plant Science (2019), 10:1168 DOI: 10.3389/fpls.2019.01168.



Baaske J/Gonschorek P, Engesser R, Dominguez-Monedero A, Raute K, Fischbach P, Müller K, Cachat E, Schamel WWA, Minguet S, Davies JA, Timmer J, Weber W*/Zurbriggen MD* "Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells" Scientific Reports (2018) DOI: 10.1038/s41598-018-32929-7 *Corresponding authors

Chatelle C, Ochoa-Fernandez R, Engesser R, Schneider N, Beyer HM, Jones A, Timmer J, Zurbriggen MD*/Weber W* "A green light-responsive system for the control of transgene expression in mammalian and plant cells" ACS Synthetic Biology (2018) DOI: 10.1021/acssynbio.7b00450 *Corresponding authors

Abbas M, Hernandez-Garcia J, Pollmann S, Samodelov SL, Kolb M, Friml J, Hammes UZ, Zurbriggen MD, Blazquez MA, Alabadi D "Auxin methylation is required for differential growth in Arabidopsis" Proceedings of the National Academy of Sciences (PNAS) USA (2018) DOI: 10.1073/pnas.1806565115

Beyer HM, Thomas OS, Riegel N, Zurbriggen MD, Weber W, Hörner M "Generic and reversible opto-trapping of biomolecules" Acta Biomaterialia (2018) DOI: 10.1016/j.actbio.2018.08.032

Middleton AM, Dal Bosco C, Chalp P, Nesch R, Harz H, Ren F, Bergamnn S, Wend S, Weber W, Hayaschi K-i, ZurbriggenMD, Uhl R, Ronneberger O, Palme K, Fleck C, Dovzhenko A "Data-driven modelling of intracellular auxin fluxes indicates a dominant role of the ER in controlling nuclear auxin uptake" Cell reports (2018) DOI: 10.1016/j.celrep.2018.02.074

Cagnola JI, Cerdan PD, Pacin M, Andrade A, Rodriguez V, Zurbriggen MD, Legris M, Buchovsky S, Carrillo N, Chory J, Blazquez MA; Alabadi D, Casal JJ "Long-day photoperiod enhances jasmonic acid-related plant defense" Plant Physiology (2018) DOI: 10.1104/pp.18.00443

Beyer HM, Engesser R, Hörner M, Koschmieder J, Beyer P, Timmer J, Zurbriggen MD, Weber W "Synthetic biology makes materials count" Advanced Materials (2018), DOI: 10.1002/adma.201800472



Samodelov SL and Zurbriggen MD “Quantitatively understanding plant signalling: novel theoretical-experimental approaches” Trends in Plant Science (2017) 22(8) DOI: 10.1016/j.tplants.2017.05.006

Winkler M, Niemeyer M, Hellmuth A, Janitza P, Christ G, Samodelov SL, Wilde V, Majovsky P, Trujillo M, Zurbriggen MD, Hoehenwarter W, Quint M, Calderon Villalobos LIA “Variation in auxin sensing guides AUX/IAA transcriptional repressor ubiquitylation and destruction” Nature Communications (2017) 8:15706 DOI: 10.1038/ncomms15706

Pierella Karlusich JJ*/Zurbriggen MD*, Shahinnia F, Sonnewald S, Sonnewald U, Hosseini SA, Hajirezaei M-R, Carrillo N “Chloroplast redox status modulates genome-wide plant responses during the non-host interaction of tobacco with the hemibiotrophic bacterium Xanthomonas campestris pv vesicatoria” Frontiers in Plant Sciences (2017) 8:1158 DOI: 10.3389/fpls.2017.01158 *Equal contribution.

Iglesias MJ, Sellaro R, Zurbriggen MD, Casal JJ “Multiple links between shade avoidance and auxin networks” Journal of Experimental Botany (2017) DOI: 10.1093/jxb/erx295



Samodelov SL, Beyer HM, Guo X, Augustin M, Jia K-P, Beyer P, Weber W, Al-Babili S, Zurbriggen MD “StrigoQuant: a genetically encoded biosensor for quantifying strigolactone activity and specificity” Science Advances (2016) 2:e1601266 DOI: 10.1126/sciadv.1601266

Smith RW, Helwig B, Westphal AH, Pel E, Hörner M, Beyer HM, Samodelov SL, Weber W, Zurbriggen MD, Borst JW and Fleck C “Unearthing the transition rates between photoreceptor conformers”. BMC Systems Biology (2016 )10(1):110 DOI: 10.1186/s12918-016-0368-y

Braguy J and Zurbriggen MD "Synthetic strategies for plant signalling studies: molecular toolbox and orthogonal platforms" Plant J (2016) 87(1):118-38 DOI: 10.1111/tpj.13218

Ochoa-Fernandez R, Samodelov SL, Brandl SM, Wehinger E, Müller K, Weber W, Zurbriggen MD. "Optogenetics in Plants: Red/Far-Red Light Control of Gene Expression." Optogenetics - Methods Mol Biol. (2016) 1408:125-39. DOI: 10.1007/978-1-4939-3512-3_9



Beyer HM, Juillot S, Herbst K, Samodelov SL, Müller K, Schamel WW, Römer W, Schäfer E, Nagy F, Strähle U, Weber W and Zurbriggen MD, "Red light-regulated reversible nuclear localization of proteins in mammalian cells and zebra fish". ACS Synthetic Biology (2015) 4(7) DOI: 10.1021/acssynbio.5b00004 Cover Article Issue July 2015

Kolar K, Wischhusen HM, Müller K, Karlsson M, Weber W and Zurbriggen MD, "A synthetic mammalian network to compute population borders based on engineered reciprocal cell-cell communication". BMC Systems Biology (2015) 9:97 DOI: 10.1186/s12918-015-0252-1

Müller K, Zurbriggen MD and Weber W, "An optogenetic upgrade for the TET-OFF System". Biotechnology and Bioengineering (2015) 112(7):1483-7 DOI: 10.1002/bit.25562

Juillot S, Beyer HM, Madl J, Weber W, Zurbriggen MD and Römer W, "Signalling to the nucleus under the control of light and small molecules". Molecular BioSystems (2015) 12:345-349 DOI: 10.1039/c5mb00763a

Beyer HM, Gonschorek P, Samodelov SL, Meier M, Weber W and Zurbriggen MD, "AQUA Cloning: a versatile and simple enzyme-free cloning approach". PLOS One (2015) 10:e0137652 DOI: 10.1371/journal.pone.0137652



Müller K, Engesser R, Timmer J, Zurbriggen MD and Weber W, "Orthogonal optogenetic triple-gene control in mammalian cells" ACS Synthetic Biology (2014) 3(11), 796-8901 DOI: 10.1021/sb500305v

Müller K, Naumann S, Weber W and Zurbriggen MD, "Optogenetics for gene expression in mammalian cells" Biological Chemistry (2014) 396(2), 145-152 DOI: 10.1515/hsz-2014-0199

Ketterer S, Hövermann D, Gübeli RJ, Bartels-Burgahn F, Riewe D, Altmann T, Zurbriggen MD, Junker B, Weber W and Meier M, "Transcription factor sensor system for parallel quantification of metabolites on-chip" Analytical Chemistry (2014) 86(24), 12152-12158 DOI: 10.1021/ac503269m

Müller K, Zurbriggen MD and Weber W, "Control of gene expression using a red/far-red light-responsive bi-stable toggle switch" Nature Protocols (2014) 9(3), 622-632 DOI: 10.1038/nprot.2014.038

Müller K, Siegel D, Rodríguez Jahnke F, Gerrer K, Wend S, Decker EL, Reski R, Weber W and Zurbriggen MD, "A red light-controlled synthetic gene expression switch for plant systems" Molecular BioSystems (2014) 10, 1679-1688 DOI: 10.1039/c3mb70579j

Cabello JV, Lodeyro AF and Zurbriggen MD, "Novel perspectives for the engineering of abiotic stress tolerance" Current Opinion in Biotechnology (2014) 26, 62-70 DOI: 10.1016/j.copbio.2013.09.011

Wend S, Wagner HJ, Müller K, Zurbriggen MD, Weber W and Radziwill G, "Optogenetic control of kinase activity in mammalian cells" ACS Synthetic Biology (2014) 3(5):280-285 DOI: 10.1021/sb400090s



Müller K and Zurbriggen MD, "Licht-gesteuerte Kontrolle der Genexpression in Säugerzellen" BIOspektrum (2013) 06.13 DOI:10.1007/s12268-013-0364-3

Wend S, Dal Bosco C, Kämpf MM, Ren F, Palme K, Weber W, Dovzhenko A and Zurbriggen MD, "A quantitative ratiometric sensor for time-resolved analysis of auxin dynamics" Scientific Reports (2013) 3:2052 DOI: 10.1038/srep02052

Müller K, Engesser R, Schulz S, Steinberg T, Tomakidi P, Weber C, Ulm R, Nagy F, Timmer J, Zurbriggen MD and Weber W, "Multi-chromatic control of mammalian gene expression and signaling" Nucleic Acids Research (2013) 41(12), e124 DOI: 10.1093/nar/gkt340

Müller K, Engesser R, Timmer J, Nagy F, Zurbriggen MD and Weber W, "Synthesis of phycocyanobilin in mammalian cells" Chemical Communications (2013) 49(79), 8970-8972 DOI: 10.1039/c3cc45065a

Müller K, Engesser R, Metzger S, Schulz S, Kämpf M, Busacker M, Steinberg T, Tomakidi P, Ehrbar M, Nagy F, Timmer J, Zurbriggen MD and Weber W, "A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells" Nucleic Acids Research (2013) 41(7), e77 DOI: 10.1093/nar/gkt002



Checa SK, Zurbriggen MD and Soncini FC, "Bacterial signaling systems as platforms for rational design of new generations of biosensors" Current Opinion in Biotechnology (2012) 23(5), 766-772 DOI: 10.1016/j.copbio.2012.05.003

Kämpf MM, Engesser R, Busacker M, Hörner M, Karlsson M, Zurbriggen MD, Fussenegger M, Timmer J and Weber W, "Rewiring and dosing of systems modules as a design approach for synthetic mammalian signaling networks" Molecular BioSystems (2012) 8(6), 1824-1832 DOI: 10.1039/c2mb05509k

Zurbriggen MD, Moor A and Weber W, "Plant and bacterial systems biology as a platform for plant synthetic bio(techno)logy" Journal of Biotechnology (2012) 160(1-2), 80-90 DOI: 10.1016/j.jbiotec.2012.01.014



Zurbriggen MD, Carrillo N and Hajirezaei M-R. "ROS signaling in the hypersensitive response: when, where and what for?" Plant Signaling and Behavior (2010) 5(4), 393-396 DOI: 10.4161/psb.5.4.10793

Zurbriggen MD, Hajirezaei M-R and Carrillo N. "Engineering the future. Development of transgenic plants with enhanced tolerance to adverse environments" Biotechnology and Genetic Engineering Reviews (2010) 27, 33-56 DOI: 10.1080/02648725.2010.10648144



Zurbriggen MD, Carrillo N, Tognetti VB, Melzer M, Peisker M, Hause B and Hajirezaei M-R. "Chloroplast-generated reactive oxygen species play a major role in localised cell death during the non-host interaction between tobacco and Xanthomonas campestris pv. vesicatoria" Plant Journal (2009) 60, 962-973 DOI: 10.1111/j.1365-313X.2009.04010.x



Zurbriggen MD, Tognetti VB, Fillat MF, Hajirezaei M-R, Valle EM and Carrillo N. From the cover: "Combating stress with flavodoxin: a promising route for crop improvement" Trends in Biotechnology (2008) 26(10), 531-537 DOI: 10.1016/j.tibtech.2008.07.001. Cover Story of issue (10)26.

Böttcher C, Centeno D, Freitag J, Höfgen R, Köhl K, Kopka J, Kroymann J, Matros A, Mock HP, Neumann S, Pfalz M, von Roepenack-Lahaye E, Schauer N, Trenkamp S, Zurbriggen MD, Fernie AR. "Teaching (and learning from) metabolomics: The 2006 PlantMetaNet ETNA Metabolomics Research School" Physiologia Plantarum (2008) 132, 136-149 DOI: 10.1111/j.1399-3054.2007.00990.x



Tognetti V*/Zurbriggen MD*, Morandi E, Fillat M, Valle E, Hajirezaei M-R and Carrillo N. From the cover: "Enhanced plant tolerance to iron starvation by functional substitution of chloroplast ferredoxin with a bacterial flavodoxin" Proceedings of the National Academy of Sciences (PNAS) USA (2007) 104, 11495-11500. DOI: 10.1073/pnas.0704553104. From the cover article of issue 104. *Equal contribution.

Zurbriggen MD, Tognetti V and Carrillo N. "Stress-inducible Flavodoxin from photosynthetic microorganisms. The mistery of Flavodoxin loss from the plant genome'' Review. IUBMB Life (2007) 59(4), 355-60 DOI: 10.1080/15216540701258744



Rodriguez R, Lodeyro A, Poli H, Zurbriggen MD, Peisker M, Palatnik J, Tognetti V, Tschiersch H, Hajirezaei M, Valle E and Carrillo N. "Transgenic tobacco plants overexpressing chloroplastic Ferredoxin-NADP(H) reductase display normal rates of photosynthesis and increased tolerance to oxidative stress" Plant Physiology (2007) 143, 639-649. Editorial remarked article of issue 143. Book chapters peer reviewed, miscelaneous

Bühler B, Hollmann F, Junker B, Junne S, Küpfer L, Mao L, Marienhagen J, Muffler K, Noack S, Olbrich C, Rihko-Struckmann L, Schallmey A, Schmid J, Stafforst T, Steingroewer J and Zurbriggen MD. DECHEMA Diskussionspapier "Biotechnologie - der Schlüssel zur Bioökonomie". (2014)DECHEMA Zukunfstforum Biotechnologie. DECHEMA Gesellschaft für Chemische Technik und Biotechnologie, Frankfurt. http://biotech.dechema.de/zukunft

Rebmann B, van Hoogevest P, Zurbriggen MD and Weber W. "Spatiotemporally controlled delivery of biopharmaceuticals" In Animal Cell Biotechnology (Hansjörg Hauser and Roland Wagner, eds) (2015), pp 649-691. De Gruyter, Berlin/München/Boston. ISBN: 978-3-11-027886-6.

Zurbriggen MD*, Carrillo N and Hajirezaei MR. "Use of cyanobacterial proteins to engineer new crops"In Recent Advances in Plant Biotechnology (Kirakosyan, A. and Kaufman, P., eds) (2009), pp 65-88. Springer, New York, NY. ISBN: 978-1-4419-0193-4. 409 p. *Corresponding author.

Tognetti V*/Zurbriggen MD*, Valle EM, Carrillo N. Morandi E, Melzer M, Hajirezaei M-R and Fillat M. "Recovering the cyanobacterial heritage in land plants: the case of flavodoxin". In Flavins and Flavoproteins (Frago S, Gómez-Moreno C and Medina M eds.), (2008) Vol. 16, pp. 527-536, Prensas Universitarias de Zaragoza. ISBN: 978-8-4773-3017-4. 628 p. *Equal contribution.

Zurbriggen MD, Tognetti V, Valle EM and Carrillo N. "Cyanobacterial Flavodoxin provides multiple stress tolerance" ISB News Report (Irwin, R., ed.), (2007). Vol. 9-07, pp. 1-5. Information Systems for Biotechnology, Virginia Tech, Vicksburg, VA, US Department of Agriculture (USDA).



Weber W, Zurbriggen MD, Rebmann B (12/2013). Reversible PEGylation of nanocarriers.European Patent Application EP13195337.4

Weber W, Müller K, Zurbriggen MD, Kämpf M, Nagy F (2012). A light regulated transgene expression system.European Patent Application 12004422.7-2403 / International Patent Application PCT/EP2013/001650

Carrillo N, Giró M, Lodeyro A and Zurbriggen MD (2012). Stress Tolerant Plants.European Patent EP2464733

Carrillo N, Giró M, Lodeyro A and Zurbriggen MD (2011). Stress Tolerant Plants.International Patent WO2011/018662A1

Carrillo N, Giró M, Lodeyro A and Zurbriggen MD (2010). Stress Tolerant Plants.United States Patent US13/389665