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24. Iwaï H*, Beyer HM, Johansson JEM, Li M, Wlodawer A. The three-dimensional structure of the Vint domain from Tetrahymena thermophila suggests a ligand-regulated cleavage mechanism by the HINT fold. FEBS Lett. 2024 Feb 13. doi: 10.1002/1873-3468.14817.

23. Wagner C§, Urquiza-Garcia U§, Zurbriggen MD*, Beyer HM*. GMOCU: Digital Documentation, Management, and Biological Risk Assessment of Genetic Parts. Adv Biol (Weinh). 2024 Jan 23:e2300529. doi: 10.1002/adbi.202300529. GitHub.

22. Deen-Rozalen O, Nieke M, Shumka S, Beyer HM*, Matias D. Zurbriggen*. The optogenetic landscape of the mitochondrion. In "The Dynamic Nature of Mitochondria: from Ultrastructure to Health and Disease (1st ed.)". CRC Press. 2024, Reichert, A.S. (Ed.). doi: 10.1201/9781003221180.

21. Jang J, Tang K, Youn J, McDonald S, Beyer HM, Zurbriggen MD, Uppalapati M, Woolley GA. Engineering of bidirectional, cyanobacteriochrome-based light-inducible dimers (BICYCL)s. Nat Methods. 2023 Feb 23. doi: 10.1038/s41592-023-01764-8.

20. Molinari PE, Krapp AR, Weiner A, Beyer HM, Kondadi AK, Blomeier T, Lopez M, Bustos-Sanmamed P, Tever E, Weber W, Reichert AS, Calcaterra NB, Beller M, Carrillo N*/Zurbriggen MD* “NERNST: a genetically-encoded ratiometric non-destructive sensing tool to estimate NADP(H) redox status in bacterial, plant and animal systems”. Nature Communications (2023). Nat Commun. 2023 Jun 6;14(1):3277. doi: 10.1038/s41467-023-38739-4.

19. Beyer HM, Iwaï, H. Structural basis for the propagation of endonuclease-associated inteins. Front. Mol. Biosci. 2022 Feb 08. doi: 10.3389/fmolb.2022.855511.

18. Tang K, Beyer HM, Zurbriggen MD, Gärtner W. The Red Edge: Bilin-Binding Photoreceptors as Optogenetic Tools and Fluorescence Reporters. Chem Rev. 2021 Dec 22;121(24):14906-14956. doi: 10.1021/acs.chemrev.1c00194. 

17. Hiltunen MK, Beyer HM, Iwaï H. Mini-Intein Structures from Extremophiles Suggest a Strategy for Finding Novel Robust Inteins. Microorganisms. 2021 Jun 5;9(6):1226. doi: 10.3390/microorganisms9061226.

16. Blomeier T, Fischbach P, Koch LA, Andres J, Miñambres M, Beyer HM, Zurbriggen MD. Blue Light-Operated CRISPR/Cas13b-Mediated mRNA Knockdown (Lockdown). Adv Biol (Weinh). 2021 May;5(5):e2000307. doi: 10.1002/adbi.202000307.

15. Beyer HM, Virtanen SI, Aranko AS, Mikula KM, Lountos GT, Wlodawer A, Ollila OHS, Iwaï H. The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms. Int J Mol Sci. 2020 Nov 7;21(21):8367. doi: 10.3390/ijms21218367.

14. Oeemig JS, Beyer HM, Aranko AS, Mutanen J, Iwaï H. Substrate specificities of inteins investigated by QuickDrop-cassette mutagenesis. FEBS Lett. 2020 Oct;594(20):3338-3355. doi: 10.1002/1873-3468.13909.

13. Beyer HM, Mikula KM, Li M, Wlodawer A, Iwaï H. The crystal structure of the naturally split gp41-1 intein guides the engineering of orthogonal split inteins from cis-splicing inteins. FEBS J. 2020 May;287(9):1886-1898. doi: 10.1111/febs.15113

12. Ciragan A, Backlund SM, Mikula KM, Beyer HM, Samuli Ollila OH, Iwaï H. NMR Structure and Dynamics of TonB Investigated by Scar-Less Segmental Isotopic Labeling Using a Salt-Inducible Split Intein. Front Chem. 2020 Mar 19;8:136. doi: 10.3389/fchem.2020.00136.

11. Beyer HM, Iwaï H. Off-Pathway-Sensitive Protein-Splicing Screening Based on a Toxin/Antitoxin System. Chembiochem. 2019 Aug 1;20(15):1933-1938. doi: 10.1002/cbic.201900139

10. Beyer HM, Mikula KM, Kudling TV, Iwaï H. Crystal structures of CDC21-1 inteins from hyperthermophilic archaea reveal the selection mechanism for the highly conserved homing endonuclease insertion site. Extremophiles. 2019 Nov;23(6):669-679. doi: 10.1007/s00792-019-01117-4

9. Beyer HM§, Thomas OS§, Riegel N, Zurbriggen MD, Weber W, Hörner M. Generic and reversible opto-trapping of biomolecules. Acta Biomater. 2018 Oct 1;79:276-282. doi: 10.1016/j.actbio.2018.08.032

8. Beyer HM, Engesser R, Hörner M, Koschmieder J, Beyer P, Timmer J, Zurbriggen MD, Weber W. Synthetic Biology Makes Polymer Materials Count. Adv Mater. 2018 May;30(21):e1800472. doi: 10.1002/adma.201800472

7. Chatelle C, Ochoa-Fernandez R, Engesser R, Schneider N, Beyer HM, Jones AR, Timmer J, Zurbriggen MD, Weber W. A Green-Light-Responsive System for the Control of Transgene Expression in Mammalian and Plant Cells. ACS Synth Biol. 2018 May 18;7(5):1349-1358. doi: 10.1021/acssynbio.7b00450

6. Smith RW, Helwig B, Westphal AH, Pel E, Hörner M, Beyer HM, Samodelov SL, Weber W, Zurbriggen MD, Borst JW, Fleck C. Unearthing the transition rates between photoreceptor conformers. BMC Syst Biol. 2016 Nov 25;10(1):110. doi: 10.1186/s12918-016-0368-y

5. Samodelov SL, Beyer HM, Guo X, Augustin M, Jia KP, Baz L, Ebenhöh O, Beyer P, Weber W, Al-Babili S, Zurbriggen MD. StrigoQuant: A genetically encoded biosensor for quantifying strigolactone activity and specificity. Sci Adv. 2016 Nov 4;2(11):e1601266. doi: 10.1126/sciadv.1601266

4. Juillot S, Beyer HM, Madl J, Weber W, Zurbriggen MD, Römer W. Signalling to the nucleus under the control of light and small molecules. Mol Biosyst. 2016 Feb;12(2):345-9. doi: 10.1039/c5mb00763a

3. Beyer HM, Gonschorek P, Samodelov SL, Meier M, Weber W, Zurbriggen MD. AQUA Cloning: A Versatile and Simple Enzyme-Free Cloning Approach. PLoS One. 2015 Sep 11;10(9):e0137652. doi: 10.1371/journal.pone.0137652

2. Beyer HM§, Juillot S§, Herbst K§, Samodelov SL, Müller K, Schamel WW, Römer W, Schäfer E, Nagy F, Strähle U, Weber W, Zurbriggen MD. Red Light-Regulated Reversible Nuclear Localization of Proteins in Mammalian Cells and Zebrafish. ACS Synth Biol. 2015 Sep 18;4(9):951-8. doi: 10.1021/acssynbio.5b00004.

1. Beyer HM, Naumann S, Weber W, Radziwill G. Optogenetic control of signaling in mammalian cells. Biotechnol J. 2015 Feb;10(2):273-83. doi: 10.1002/biot.201400077


§ Equal contribution